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Episode · Sep 18, 2026 · 1 hr 55 min

The Doctor Who Got Sick 22 Times Before Anyone Asked Why

with Dr. Clay Moss

Dr. Clay Moss is a physical medicine and rehabilitation resident who plans to open a practice focused on the kind of care he needed as a teenager.

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Summary

Clay Moss spent four years at Ole Miss getting strep throat about every other month, despite training six days a week. After 22 documented cases, he had his tonsils removed, then got the worst strep infection of his life six weeks later. At medical school in Jackson, he watched classmates move from all-nighters to stimulants, sleep aids and antidepressants. He describes the time pressure doctors face and why he hopes to build a practice with more time for patients.

A 12.5-hour plastic surgery case helped Clay realize he did not want to become a surgeon, and a later rotation introduced him to physical medicine and rehabilitation. He also recounts a panic attack that began in college, a Xanax prescription he declined, and the sleep, food, meditation and blood work he tried instead. After a COVID booster, Clay says a softball-sized lymph node lasted six weeks; Ken describes chest pain, two ER visits and lasting brain fog.

The conversation covers strength training, muscle and aging, hormone therapy, sun exposure, tap water, low-dose lithium and sauna use. Clay explains how his experience with repeated illness and rushed care shaped the clinic he hopes to open after residency.

Show notes

Clay Moss looked like the healthiest guy at Ole Miss. He trained six days a week and got strep throat every other month for four straight years. Twenty-two documented cases. Every visit ended the same way: a steroid shot, a round of antibiotics, see you next time. Nobody asked how he was sleeping, what he was eating, or how much caffeine he was running on.

He got his tonsils out after graduation. Six weeks later he had the worst strep of his life.

Then medical school in Jackson, Mississippi, the only MD program in the state. He watched classmates go from all-nighters to Adderall to Xanax to sleep aids to antidepressants, and by fourth year he was sitting in the lecture hall where it all started, listening to fifteen of them compare prescriptions. When a doctor offered him Xanax for the panic attacks he had been having since sophomore year of college, he said no and started with sleep, food, meditation, and blood work instead.

This week I sat down with Dr. Clay Moss, a Gulf Breeze kid who used to peek through the fence at the Andrews Institute on the walk home from middle school. We get into the 12.5-hour surgery that ended his surgeon dream four hours in, opening his Match Day letter on stage, why your doctor only gets 5 to 12 minutes with you, and what happened to him after the COVID booster that he didn’t feel he could say out loud in med school.

We also get into the stuff you can use tomorrow. Why he picks the barbell over the treadmill, why a broken hip after 65 is so dangerous, hormone therapy for women, sun versus sunscreen, tap water, low-dose lithium, and what four sauna sessions a week does for you.

Clay has ten months of residency left and 800,000 people following his work. Then he opens the practice 18-year-old Clay needed. Hope you guys enjoy this one.

Follow Clay: @drclaymoss

Read the transcript

Transcript

Made from YouTube's automatic captions and lightly corrected, so a few words and names may be off. Click a time to play the video from there.

Ken Rideout

All right, today's guest, my good friend and functional medicine upand cominging superstar, Dr. Clay Moss.

Dr. Clay Moss

What's up, man?

Ken Rideout

Welcome to the show, brother.

Dr. Clay Moss

Thank you. Honored to be here.

Ken Rideout

Dying to talk to you about all the latest and greatest in functional medicine.

Dr. Clay Moss

Well, I'll do my best. Let's get into it, I guess.

Ken Rideout

Where'd you grow up?

Dr. Clay Moss

Uh, so I grew up in the panhandle of Florida, little town called Gulf Breeze. Born and raised there. My dad, my parents actually ended up there cuz my dad was a Tennessee guy. He lived in Memphis. graduated [snorts] from college and decided

Ken Rideout

Where'd you go to school?

Dr. Clay Moss

So, I went to Ole Miss. He was a Mississippi State guy. My mom was an Ole Miss girl.

Ken Rideout

Just missed your man Dexter McCcluster. Superstar running back. Were you there at the same time he was?

Dr. Clay Moss

No, I was there maybe three or four years after him.

Ken Rideout

Okay.

Dr. Clay Moss

Yeah. But I like grew up with a Mcccluster jersey and everything.

Ken Rideout

When you see Dexter McCluster, there is no one is going to mistake him for an NFL player. No disrespect. He's about 58 and a quarter and 165 lbs.

Dr. Clay Moss

He was like in that Jeff Dempse University of Florida era where they were all just like super fast and short

Ken Rideout

Dude. Savage. I mean his career stats are crazy but when you see him you're like that's him.

Dr. Clay Moss

It's nuts. But so he ended up in Pensacola cuz my my dad actually graduated college and he wanted to go live on the coast and he you know I think his his so his dad passed away and he was like look no other time that I'm be able to do this.

So he bought a housebo down there. He drove a motorcycle from Memphis down to Pensacola, which

Key takeaways

  • Repeated infections can prompt a broader look at sleep, food and stimulant use alongside treatment for immediate symptoms.
  • Clay started with sleep, food, meditation and blood work when he declined a Xanax prescription for panic attacks.
  • A long and difficult surgery changed the kind of medicine Clay wanted to practice.
  • Clay argues that strength and muscle deserve attention alongside cardio as people age.
  • Knowing why you take a medication or supplement can help you make a more informed choice.
  • Short appointments make it useful to arrive with clear questions and a concise account of symptoms.

Nowhere to Hide

A weekly letter from Ken Rideout about doing the uncomfortable part, and the reasons we use to avoid it.

It starts with 3 Days, 3 Hard Things: one short story from Ken and one hard thing to do, every day for three days. Then one letter a week.